Abstract
The first total synthesis of xestospongenyne, a marine brominated polyunsaturated lipid with remarkable pancreatic lipase inhibitory activity (IC<sub>50</sub> = 0.61 μM), was achieved from commercially available hept-6-yn-1-ol with 13% overall yield. This synthesis will permit further biological study of xestospongenyne and its analogues, with the aim of producing an antiobesity drug.
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