First Total Synthesis of an Analogue of Montbretyl 12-Methyl Ether

Abstract

The first total synthesis of the title compound 1 was accomplished starting from α-cyclocitral and benzyl triphenylphosphonium chloride 3 in seven steps via a strategy of AC→ABC. In the synthesis, t-BuOK/ t-BuOH system was utilised for enolisation and the iso-propyl group was introduced in the last step.