First Tandem‐Type One‐Pot Process Combining Asymmetric Organo‐ and Biocatalytic Reactions in Aqueous Media Exemplified for the Enantioselective and Diastereoselective Synthesis of 1,3‐Diols

Abstract

A suitable “process window” was identified for the combination of an asymmetric organocatalytic aldol reaction and subsequent biocatalytic reduction in aqueous medium, which thus enabled the enantio‐ and diastereoselective synthesis of 1,3‐diols in a tandem‐type, one‐pot process. A key feature of this one‐pot synthesis is the high 500 mm loading of the aldehyde substrate used as a starting material.