First stereoselective total synthesis of cryptomoscatone E1 and synthesis of (+)-goniothalamin via an asymmetric acetate aldol reaction

Abstract

A stereoselective total synthesis of (+)-goniothalamin and cryptomoscatone E1 have been described. The synthetic strategy involves an asymmetric acetate aldol reaction, Evans acetal intramolecular oxa-Michael reaction, ring-closing metathesis, Horner–Wadsworth–Emmons reaction and lactonization as the key steps.