First report on seroprevalence and risk factors of dengue virus in Jordan

Abstract

There are no data available on dengue epidemiology in Jordan. This is the first study of the seroprevalence and risk factors of dengue virus (DENV) infection in Jordan. Sera samples from 892 apparently healthy individuals from all over Jordan were tested for DENV by enzyme-linked immunosorbent assay and a validated questionnaire was completed by all participants to identify and rank possible risk factors. The seroprevalence was 24.6% (95% confidence interval 21.8 to 27.5). In univariate regression analysis, age, education, history of travel, living in rainy areas and practicing agriculture were significantly (p<0.05) associated with seropositivity. The multivariate logistic regression model showed that those who live in a rainy climate (odd ratio [OR] 1.7), are older (OR 2.3), have a history of international travel (OR 1.5) and are male with a history of international travel had a significantly greater odds of DENV seropositivity (OR 3.4). These data suggest that DENV circulates in Jordan and that cases may be imported or locally transmitted. Further research is needed to determine the circulating DENV serotypes and vectors in Jordan. Given the high rate of DENV seropositivity, dengue should be considered as a differential diagnosis in febrile diseases in Jordan, especially among populations living in rainy climates.