Abstract
AimsHLA-DPA1 is an important marker in bone marrow and organ transplantation and a highly emerging screening parameter in histocompatibility laboratories. Being highly polymorphic, it has another significant value in detecting population origins and migrations. This is the first study to assess DPA1 allele frequencies in an Arab population. MethodsThe HLA DPA1 alleles were identified using the One-Lambda assays on a Luminex reverse SSO DNA typing system. Our study included 101 individuals coming from different Lebanese geographical areas representing the different communities and religious sects of the country. ResultsWe compared the results of this study to 16 different populations and found very interesting similarities and differences between Lebanese people and individuals of European ancestry. ConclusionThis study is the first to describe the different allelic frequencies of HLA-DPA1 in the Lebanese population and will serve as a template that can be later used for disease association studies both at the level of the country and internationally.
Highlights
Human leukocyte antigen (HLA) compatibility is necessary for a desirable organ/stem cell transplantation and tests performed on donors and recipients determine the extent of this compatibility
HLA-DQ and HLA-DR have shown to be the main players in controlling graft rejection or acceptance, yet the DP locus has its share in deciding the final outcome
The frequencies of the various HLA-DPA1 alleles reported in this study are listed in Table 1 where results are compared with the frequencies of several alleles reported in different populations labeled from 1 to 17
Summary
Human leukocyte antigen (HLA) compatibility is necessary for a desirable organ/stem cell transplantation and tests performed on donors and recipients determine the extent of this compatibility. In accordance with its importance, the effect of HLA-DPA1 was investigated in various clinical diseases such as inflammatory bowel disease (Lantermann et al, 2002), post-streptococcal acute glomerulonephritis (Mori et al, 1996), ankylosing spondylitis (Díaz-Peña et al, 2013), systemic lupus erythematosus and systemic vasculitis (Gan et al, 2015) It was studied in seropositive chronic hepatitis B patients on IFN treatment (Cheng et al, 2014). Due to HLA-DPA1 and HLA-DPB1 variability and polymorphism, these genes can vary greatly among different ethnic groups. They are of great importance in human immunogenetics and in providing information about human population diversity. This study is the first to describe the different allele frequency in the Lebanese population and can be later used for disease association studies
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