Abstract
Background Uric acid is a powerful free-radical scavenger in humans, but hyperuricemia may induce insulin resistance and beta-cell dysfunction. The study aimed to evaluate the association between hyperuricemia and hyperglycemia, considering the confounding factors in a Vietnamese population. Methods A population-based cross-sectional study recruited 1542 adults aged 50 to 70 years to collect data on socioeconomic status, lifestyle factors, and clinical patterns. Associations between hyperuricemia and hyperglycemia (isolated impaired fasting glucose (IFG), isolated impaired glucose tolerance (IGT), combined IFG-IGT, and type 2 diabetes (T2D)) were evaluated by multinomial logistic regression analysis in several models, adjusting for the confounding factors including socioeconomic status, lifestyle factors, and clinical measures. Results Uric acid values were much higher in IFG, IFG-IGT, and T2D groups compared to those in the normal glucose tolerance (NGT) group. The significant association of hyperuricemia with IFG, IFG-IGT, and T2D was found in the model unadjusted and remained consistently in several models adjusted for socioeconomic status, lifestyle factors, and clinical patterns. In the final model, the consistent hyperglycemia risk was found in total sample (OR = 2.23 for IFG, OR = 2.29 for IFG-IGT, and 1.75 for T2D, P ≤ 0.006) and in women (OR = 2.90 for IFG, OR = 3.96 for IFG-IGT, and OR = 2.49 for T2D, P < 0.001) but not in men. Conclusions It is the first report in Vietnamese population suggesting the significant association of hyperuricemia with IFG, IFG-IGT, and T2D; and the predominant association was found in women than in men, taken into account the confounding factors.
Highlights
Uric acid is produced during the exogenous metabolic breakdown of purines from dietary intake, and it is a product from the endogenous degradation from dead cells
In Japanese men, uric acid was negatively associated with diabetes in a crosssectional study [16], while prospective studies reported inconsistent findings that serum uric acid (SUA) level was not associated [17] or associated [18] with an increased risk for type 2 diabetes. e inconsistent association between elevated SUA and type 2 diabetes may be explained by confounding factors including socioeconomic status, lifestyle-related factors, and clinical measures
A recommendation that the correlation between SUA and type 2 diabetes requires further evaluation has been noted from a systematic review and meta-analysis including 970 studies in 61,714 participants [19]. erefore, we conducted a population-based cross-sectional study to investigate the association between hyperuricemia and hyperglycemia including impaired fasting glucose, impaired glucose tolerance, and type 2 diabetes, considering the confounding factors in a Vietnamese population. e gender difference in the association was reported
Summary
Uric acid is produced during the exogenous metabolic breakdown of purines from dietary intake, and it is a product from the endogenous degradation from dead cells. E inconsistent association between elevated SUA and type 2 diabetes may be explained by confounding factors including socioeconomic status, lifestyle-related factors, and clinical measures (body mass index, blood pressures, and dyslipidemia). Erefore, we conducted a population-based cross-sectional study to investigate the association between hyperuricemia and hyperglycemia including impaired fasting glucose, impaired glucose tolerance, and type 2 diabetes, considering the confounding factors in a Vietnamese population. Associations between hyperuricemia and hyperglycemia (isolated impaired fasting glucose (IFG), isolated impaired glucose tolerance (IGT), combined IFG-IGT, and type 2 diabetes (T2D)) were evaluated by multinomial logistic regression analysis in several models, adjusting for the confounding factors including socioeconomic status, lifestyle factors, and clinical measures. It is the first report in Vietnamese population suggesting the significant association of hyperuricemia with IFG, IFG-IGT, and T2D; and the predominant association was found in women than in men, taken into account the confounding factors
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
