Abstract
Sarcoidosis can present as an acute form or take a chronic course. One of the acute presentations is Löfgren’s syndrome (LS), consisting of the symptom triad of bilateral hilar lymphadenopathy, erythema nodosum, and ankle periarthritis. In addition, there are occasional reports of sarcoid-like reactions following drug exposures. Nevertheless, reports of sarcoidosis or LS after vaccination have not been published. Here, we report two cases of de novo LS in a temporal association with different vaccines against the new coronavirus SARS-CoV-2. One patient developed the first symptoms three days after the second vaccination (first vaccination ChadOx-1, Astra Zeneca; second vaccination CX-024414, Moderna); in the second patient, symptoms started 28 days after the first vaccination (ChadOx-1, Astra Zeneca). Both patients eventually required treatment with glucocorticoids. Both patients achieved clinical improvement with treatment. In conclusion, we report the first two cases of LS shortly after SARS-CoV-2 vaccination.
Highlights
National vaccination programs have been employed to control the ongoing SARS-CoV-2 pandemic and reduce the number of subsequent COVID-19 cases
They differ by their mechanism of antibody induction [1]
After reports of adverse events occurring after vaccination ranging from relatively mild cutaneous reactions [2] to severe and potentially fatal conditions, including vaccine-induced thrombocytopenia and thrombosis (VITT) [3], people may be hesitant to receive vaccines
Summary
CoV-2 pandemic and reduce the number of subsequent COVID-19 cases. This is especially relevant in light of emerging variants of concern throughout the world. The first patient, a 21-year-old Caucasian woman, reported a skin rash three weeks after her second SARS-CoV-2 vaccination. The second patient, a 27-year-old Caucasian man without a significant past medical history, presented with increasing ankle swelling and pain for three weeks to the ED One week earlier, he noticed an extensive reddish-violaceous rash on both lower legs. Seven weeks before ED presentation, he had received the first SARS-CoV-2 vaccination (ChAdOx1, Vaxzevria, AstraZeneca) without any relevant side effects He had painful bilateral ankle swelling with periarticular inflammation on MSK ultrasound examination.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
