Abstract
To verify the occurrence of natural Trypanosoma cruzi infection in non-human primates from a rural endemic area of the east region of Paraguay, xenodiagnosis was performed in 35 animals belonging to two species. For genotyping and T. cruzi discrete typing unit (DTU) assignment, a combination of four markers was used, including amplification products of the small (18S) and large (24Sα) subunits of ribosomal ribonucleic acid gene, the intergenic region of mini-exon gene and the heat shock protein 60 Eco-RV polymerase chain reaction-restriction fragment length polymorphism (HSP60/EcoRV-PCR-RFLP). One specimen of Sapajus cay was found positive and infected by the DTU TcII. This result constitutes the first record of natural T. cruzi infection in a sylvatic monkey in Paraguay, harbouring a DTU associated with severe Chagas disease in humans.
Highlights
Trypanosoma cruzi is the causal agent of Chagas disease, a neglected parasitic disease that is estimated to affect approximately six millions people living in 21 countries of the Americas
One specimen of Sapajus cay was found positive and infected by the discrete typing unit (DTU) TcII. This result constitutes the first record of natural T. cruzi infection in a sylvatic monkey in Paraguay, harbouring a DTU associated with severe Chagas disease in humans
This study constitutes the first report of T. cruzi infection in a monkey from Paraguay
Summary
Trypanosoma cruzi is the causal agent of Chagas disease, a neglected parasitic disease that is estimated to affect approximately six millions people living in 21 countries of the Americas. It is estimated that 60 to 80 million are under risk of infection in endemic areas (WHO, 2015). The infection for this parasite is considered primarily a zoonosis. Several species of sylvatic mammals were found naturally infected with this parasite, including over 73 genera and members of nine orders (JANSEN et al, 2015). Despite this wide range of hosts, the epidemiological importance of T. cruzi reservoirs varies according to the geographic region, the biology and ecology of these mammals
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Schedule a callMore From: Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria
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