Abstract
We describe the genetic diversity of currently transmitted strains of HIV-1 in men who have sex with men (MSM) in Buenos Aires, Argentina between 2000 and 2004. Nearly full-length sequence analysis of 10 samples showed that 6 were subtype B, 3 were BF recombinant and 1 was a triple recombinant of subtypes B, C and F. The 3 BF recombinants were 3 different unique recombinant forms. Full genome analysis of one strain that was subtype F when sequenced in pol was found to be a triple recombinant. Gag and pol were predominantly subtype F, while gp120 was subtype B; there were regions of subtype C interspersed throughout. The young man infected with this strain reported multiple sexual partners and sero-converted between May and November of 2004. This study reported for the first time the full genome analysis of a triple recombinant between subtypes B, C and F, that combines in one virus the three most common subtypes in South America.
Highlights
In Argentina, previous molecular studies have revealed the presence of two epidemics; the first, among men who have sex with men (MSM), where the viral strains are mostly subtype B, and the second among heterosexuals and injecting drug users where BF recombinants predominate [2,3]
We performed nearly full-length genetic sequencing of 10 Human Immunodeficiency Virus (HIV)-1 incident cases who seroconverted in a cohort study among MSM participants in Buenos Aires, Argentina, between the years 2002 and 2005 [6]
This study describes the first nearly full-length genome analysis of HIV-1 from MSM seroincident cases in Buenos Aires, Argentina
Summary
In Argentina, previous molecular studies have revealed the presence of two epidemics; the first, among men who have sex with men (MSM), where the viral strains are mostly subtype B, and the second among heterosexuals and injecting drug users where BF recombinants predominate [2,3]. Further sequencing studies have revealed the presence of a new CRF, the CRF12_BF [4] and subtype (page number not for citation purposes) We performed nearly full-length genetic sequencing of 10 HIV-1 incident cases who seroconverted in a cohort study among MSM participants in Buenos Aires, Argentina, between the years 2002 and 2005 [6].
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