Abstract
INTRODUCTION: Carbapenemase-resistant enterobacteria that produce the bla NDM gene are found worldwide. However, this is the first report of blaNDM in Klebsiella aerogenes in Brazil. METHODS: The identification of bacterial species was performed using anautomated system and confirmed by biochemical tests, 16S rRNA gene sequencing, and detection of resistance genes. RESULTS:The clinical isolate showed minimum inhibitory concentration resistance to meropenem and polymyxin B at 8mg/L and 4mg/L, respectively. Only the blaNDM gene was detected. CONCLUSIONS: The current report of the blaNDM gene in isolated MDR enterobacteria indicates that this gene can spread silently in a hospital setting.
Highlights
Introduction: Carbapenemase-resistant enterobacteria that produce the blaNDM gene are found worldwide. This is the first report of blaNDM in Klebsiella aerogenes in Brazil
The blaNDM-1 gene product is New Delhi metallo-beta-lactamase (NDM)-1, which hydrolyzes a wide range of β-lactam antimicrobials, including carbapenems, which are the last-resort antimicrobials in the treatment of infections caused by antimicrobial-resistant bacteria
Cynthia Regina Pedrosa Soares. e-mail: cynthiaregina@msn.com https://orcid.org/0000-0001-8915-859X Received 11 May 2020 Accepted 2 September 2020 these genes represents a challenge in the treatment of infections[1].The objective of this study was to describe the occurrence of the blaNDM gene in a clinical isolate of K. aerogenes resistant to aminopenicillin, beta-lactam + beta-lactamase inhibitors, and 1st, 2nd, 3rd, and 4th generation beta-lactams, as well as carbapenems
Summary
Abstract Introduction: Carbapenemase-resistant enterobacteria that produce the blaNDM gene are found worldwide. This is the first report of blaNDM in Klebsiella aerogenes in Brazil. Methods: The identification of bacterial species was performed using anautomated system and confirmed by biochemical tests, 16S rRNA gene sequencing, and detection of resistance genes.
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