Abstract
The world’s first porcine-to-human heart transplantation was performed at the University of Maryland School of Medicine (Baltimore, MD, USA), where a genetically modified pig heart was successfully transplanted into a 57-year-old man in the end stage of heart disease. After highly experimental surgery, the patient was able to move about freely in the absence of cardiopulmonary bypass assistance. The historic operation overcame the largest possible obstacle caused by hyperacute immune rejection and achieved a good short-term result.But the patient's condition began deteriorating, and died on March 9, 2022, two months after the transplant surgery.
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