Abstract
ABSTRACT First Person is a series of interviews with the first authors of a selection of papers published in Biology Open, helping early-career researchers promote themselves alongside their papers. Kazuko Okamoto is first author on ‘ Pressure-induced changes on the morphology and gene expression in mammalian cells’, published in BiO. Kazuko conducted the research described in this article while a research scientist in Tomonobu M. Watanabe's lab at RIKEN Center for Biosystems Dynamics Research, Kobe, Japan. She is now an assistant professor in the lab of Satoru Okuda at Nano Life Science Institute, Kanazawa University, Japan, investigating intracellular communication and transcription regulation.
Highlights
I joined the RIKEN Center for Biosystems Dynamics Research (BDR), where the focus was on the development of microscopes and imaging technology for quantitative observation of the dynamics of living biological systems
We demonstrated that hydrostatic pressure changes cellular morphology and transcription
We reported hydrostatic pressure effects on the morphology by using various types of mammalian cells
Summary
I joined the RIKEN Center for Biosystems Dynamics Research (BDR), where the focus was on the development of microscopes and imaging technology for quantitative observation of the dynamics of living biological systems. I started to use various types of microscopes. There, I analysed collective phenomena in mouse embryonic stem cells (Okamoto et al, 2018), pressure-induced effects on mammalian cells in our paper for Biology Open, and molecular dynamics of transcription factors in living cellular nuclei (Okamoto et al, 2020).
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