Abstract
Summary Summary: We report the feasibility of first pass vasodilator-stress myocardial perfusion CMR in mice on a whole-body 3Tesla scanner and demonstrate a 2.6 fold increase of stress over rest myocardial blood flow in good agreement with microspheres. Background Animal models are important to develop our understanding of the pathophysiology of cardiovascular disease and for the development of new therapies. While coronary autoregulation maintains resting myocardial blood flow (MBF) constant over a wide range of pathological conditions, MBF reserve during hyperaemic stress is impaired in several common disease processes. First pass contrast-enhanced myocardial perfusion is the standard CMR method for the estimation of MBF and MBF reserve in man, but is challenging in rodents because of the constraints related to the high temporal and spatial resolution requirements. Murine first pass myocardial perfusion at rest can be performed on a whole-body 3 Tesla CMR system. Hyperaemic myocardial stress perfusion CMR in mice has however not been reported.
Highlights
Summary Summary: We report the feasibility of first pass vasodilator-stress myocardial perfusion CMR in mice on a whole-body 3Tesla scanner and demonstrate a 2.6 fold increase of stress over rest myocardial blood flow in good agreement with microspheres
Animal models are important to develop our understanding of the pathophysiology of cardiovascular disease and for the development of new therapies
While coronary autoregulation maintains resting myocardial blood flow (MBF) constant over a wide range of pathological conditions, MBF reserve during hyperaemic stress is impaired in several common disease processes
Summary
First pass vasodilator-stress myocardial perfusion CMR in mice on a whole-body 3Tesla scanner: validation against microspheres. Summary Summary: We report the feasibility of first pass vasodilator-stress myocardial perfusion CMR in mice on a whole-body 3Tesla scanner and demonstrate a 2.6 fold increase of stress over rest myocardial blood flow in good agreement with microspheres
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