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Abstract
In the present work, we report the first bionanocomposite material formed by otoliths/ collagen/ bacterial cellulose (BC) networks (OCBC). This biomaterial is an osteoinductor or be, stimulates the bone regeneration, enabling bigger migration of the cells for formation of the bone tissue regeneration mainly because nanotolith are rich in minerals considered essential to the bone mineralization process on a protein matrix (otolin). The objective in this study was to analyze the regeneration capacity of bone defects treated with this bionanocomposite. Histological experiments shows bone tissue formation with high regularity, higher osteoblast activity and osteo-reabsorption activities areas. The results suggest the potential for this new biomaterial as a scaffold for bone tissue regeneration.
Highlights
Despite many advances in tissue engineering (TE), scientists still face significant challenges in repairing or replacing soft tissues such as tendons, ligaments, skin, liver, nerve and cartilage to improve the quality of people life
We report the first bionanocomposite material formed by otoliths/ collagen/ bacterial cellulose (BC) networks (OCBC)
We report a new bionanocomposite material formed by otoliths/collagen/bacterial cellulose (BC) networks (OCBC)
Summary
Despite many advances in tissue engineering (TE), scientists still face significant challenges in repairing or replacing soft tissues such as tendons, ligaments, skin, liver, nerve and cartilage to improve the quality of people life. Matrices are developed to support cells, promoting their differentiation and proliferation towards the formation of a new tissue. Such strategies allow for producing hybrid constructs that can be implanted in patients to induce the regeneration of tissues or replace failing or malfunctioning organs. Natural based polymers offer the advantage of being similar to biological macromolecules, which the biological environment is prepared to recognize and deal with metabolically. Owing to their similarity with the extracellular matrix (ECM), natural polymers may avoid the stimulation of chronic inflammation or immunological reactions and toxicity, often detected with synthetic polymers [2]. The nanostructure and morphological similarities with collagen make BC attractive for cell immobilization and cell support [3,4,5]
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