Abstract

We describe the first cefixime-resistant Neisseria gonorrhoeae strain in Austria that caused treatment failure.It follows the first five cases in Europe of cefixime treatment failure, reported in Norway in 2010 and the United Kingdom in 2011. Effective treatment of gonorrhoea is crucial for public health control and, at present, requires substantially enhanced awareness, more frequent test-of-cure, interaction with experts after therapeutic failure, tracing and therapy of contacts, and surveillance of gonococcal antimicrobial resistance and treatment failures worldwide.

Highlights

  • We describe the first cefixime-resistant Neisseria gonorrhoeae strain in Austria that caused treatment failure

  • We report here the first N. gonorrhoeae strain with resistance to cefixime in Austria, which caused a treatment failure with the internationally recommended first-line treatment cefixime

  • The present treatment failure was identified in an Austrian patient, the infection was contracted in Germany, which suggests that this strain may be present in the MSM community in Germany

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Summary

Rapid communications

First Neisseria gonorrhoeae strain with resistance to cefixime causing gonorrhoea treatment failure in Austria, 2011. We describe the first cefixime-resistant Neisseria gonorrhoeae strain in Austria that caused treatment failure. It follows the first five cases in Europe of cefixime treatment failure, reported in Norway in 2010 and the United Kingdom in 2011. Effective treatment of gonorrhoea is crucial for public health control and, at present, requires substantially enhanced awareness, more frequent test-of-cure, interaction with experts after therapeutic failure, tracing and therapy of contacts, and surveillance of gonococcal antimicrobial resistance and treatment failures worldwide. We report here the first Neisseria gonorrhoeae strain with resistance to cefixime in Austria, which caused a treatment failure with cefixime. It is possible that gonorrhoea will become untreatable in certain circumstances and especially some settings [1,7]

Case report
Characterisation of the cefiximeresistant Neisseria gonorrhoeae strain
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Discussion
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