Abstract
BackgroundColorectal cancer (CRC) is the second most common malignancy in the Saudi population. This study aimed to review CRC data from the Saudi Cancer Registry (SCR) in order to evaluate the prognostic factors for CRC survival in Saudi patients.MethodsThis study was a retrospective censored overall survival (OS) analysis of CRC data for the period 1994–2004 obtained from the SCR. Data were collected from all 13 administrative regions of the Kingdom of Saudi Arabia (KSA) by the SCR in collaboration with the National Information Center of the Ministry of Interior. The Kaplan-Meier method was used to calculate the cumulative survival rate, which was then stratified by gender and by period (1994–1999 versus 2000–2004). The clinico-pathological variables that might affect CRC survival were analyzed by Cox regression analysis.ResultsBetween 1994 and 2004, 549 CRC cases were diagnosed (363 [66.1%] in males and 186 [33.9%] in females). The OS for CRC during this period was 44.6% (44.7% for 1994–1999 and 44.3% for 2000–2004 [p=0.7]). There was a significant (p=0.003) discrepancy of 9.6% between the male five-year OS (41.0%) and the female five-year OS (50.6%). The five-year OS was 63.3% for patients with localized disease, 50.2% for those with regional disease, and 14.7% for patients with metastases. By Cox regression analysis, age and extent were significant prognostic factors of survival in patients with colon cancer; the risk was higher in patients with distant metastasis (hazard ratio [HR], 2.53; 95% confidence interval [CI], 1.17-5.45; p=0.01). In patients with rectal cancer, the risk was lower in males (HR, 0.66; CI, 0.45-0.98; p=0.04), but higher in patients with unknown tumor extent (HR, 3.70; 95% CI, 1.66-8.24; p=0.01).ConclusionsThe five-year OS for 1994–2004 was 44.6% for patients with CRC. More so, five-year OS based on CRC stage was generally lower than the typically reported survival rates. The establishment of a national screening program and increased access to specialized medical faculties may be necessary to improve CRC survival in the KSA.
Highlights
Colorectal cancer (CRC) is the second most common malignancy in the Saudi population
The aim of this study was to review CRC data for the period 1994–2004 based on reports from the Saudi Cancer Registry (SCR) in order to evaluate the prognostic factors for CRC survival in Saudi patients
The risk of death was higher in patients with distant metastasis (HR, 2.53; 95% confidence interval (CI), 1.17-5.45; p=0.01)
Summary
Colorectal cancer (CRC) is the second most common malignancy in the Saudi population. The highest incidence is in Australia, New Zealand and Western Europe, while the lowest is in Africa and South-Central Asia [1]. Both the incidence and mortality rates are lower in women than in men. CRC is less common in the KSA than in its counterpart Gulf Cooperation Council States and in the West, this disease was the second most common malignancy after breast cancer, ranking first among men and third among women between 1994 and 2004 [4]. The age-standardized incidence rate in 2004 was 7.3 per 100,000 men and women based on cases diagnosed from 13 Saudi Cancer Registry (SCR) geographic sites. The World Health Organization (WHO) reported that the age-standardized death rate (per 100,000 inhabitants) from CRC in the KSA was 8.3% [5]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
