Abstract
Portable inhalers release medical drugs for inhalation and are used to treat lung diseases such as Asthma, COPD, or cystic fibrosis. However, the majority of portable in-halers currently sold worldwide contain greenhouse-active propellants.Here we present a spring-actuated 3D-printed swirl nozzle that sprays an aqueous drug solution, matching propellant-containing inhalers in aerosolization time. 2-photon polymerization enables print times of 40 minutes for a monolithic device. Our 35 bar spring-operated swirl nozzle prototype achieves mean volumetric particle sizes of 12.5 µm on doses of 100 µl, aerosolized in 270 ms, as fast as a propellant-driven inhaler.
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