Abstract
This case series was set up to rescue cycles of previous non-responders to conventional AOA. Within a 2-year period eight couples showing total fertilization failure after single and double calcimycin treatment, respectively, were identified. These patients with no fertilization in two treatment cycles had all their mature oocytes treated with a ready-to-use ionomycin solution in the subsequent study cycle. Fertilization rate was found to be 31.3% (15/48). Three patients experienced recurrent fertilization failure again. Out of 5 transfers three biochemical pregnancies occurred and two of them resulted in the birth of a healthy male full-term newborn. Thus, the associated live-birth rate in this bad prognosis patient cohort was 25%. Ready-to-use ionomycin is a potential treatment option for AOA once other techniques have failed, and as such would allow for the usage of homologous instead of donor gametes.
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