First in Vivo Evidence of Lower Synaptic Density Marker in Obesity and the Relationship With Psychopathology

Ruth Asch,Sophie Holmes,Marc Potenza,Stephen Baldassarri,Robert Pietrzak,Irina Esterlis

doi:10.1016/j.biopsych.2021.02.257

First in Vivo Evidence of Lower Synaptic Density Marker in Obesity and the Relationship With Psychopathology

Ruth Asch, Sophie Holmes + Show 4 more

https://doi.org/10.1016/j.biopsych.2021.02.257

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Journal: Biological psychiatry

Publication Date: Apr 27, 2021

Affiliation: Yale University, National Center for Post Traumatic Stress Disorder

#Additive Effect Of Obesity #Synaptic Density + Show 8 more

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Abstract

Obesity often co-occurs with physical and mental disorders; however, neurochemical alterations associated with obesity are not clear, and whether there is an additive effect of obesity and comorbid mental disorders has not been well examined. Synaptic alterations contribute to mood and cognitive symptoms of psychiatric disorders and may also play a role in neuropathophysiology associated with obesity. This study examined relationships between obesity, psychiatric disorders, and synaptic density in vivo using [11C]UCB-J (which binds to synaptic glycoprotein SV2A) and positron emission tomography.

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