Abstract
Nucleic-acid-based drugs1 are a novel class of drugs with great therapeutic potential. Among these are DNAzymes,2 which contain short stretches of single-stranded DNA molecules synthesised in vitro.3 A DNAzyme can recognise through Watson-Crick basepairing a specific messenger RNA (mRNA) sequence and induce cleavage between a purine and a pyrimidine residue. Upon cleavage, the target mRNA undergoes accelerated degradation, which leads to a reduction in the concentration of the encoded protein and its related biological functions.
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