Abstract

First Haploidentical Transplant in Peru in Pediatric Patient with Bilineal Leukemia

Highlights

  • Within the group of hybrid acute leukemias, are the biphenotypic leukemias and mixed or bilineal leukemias

  • On admission to our service, molecular study (E2A/PBX1, MLL/ AF4, BCR/ABLp190, BCR/ABLp210, TEL/ AML1, AML1-ETO, FLT3-ITD and JAK2 V617F) was performed: all came up negative. He later received induction according to protocol LMA; with persistence post this chemotherapy; a second high-dose cytarabine induction was decided, achieving complete morphological remission (CR) by bone marrow aspirate (BMA) and IFT

  • Cases of leukemia are combined with bilineal Biphenotypic

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Summary

Introduction

Within the group of hybrid acute leukemias, are the biphenotypic leukemias and mixed or bilineal leukemias. With the use of monoclonal antibodies, most acute leukemias can be classified by their phenotype, and determine the degree of clonal promiscuity, according to the expression of myeloid and lymphoid antigenic markers [1,2]. These morphological and immunophenotypic features may be different and be present in a population of blasts (leukemia Biphenotypic) or two different blastic populations may be present in one single patient (bilineal leukemia). It seems important in this particular case, because of the rarity of its presentation, the prognosis and the healing alternative recently started in our institution, since opting for an unrelated donor (umbilical cord) is very expensive for our country

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