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Abstract
The first Dominique Dormont International Conference on "Viral and host determinantsof HCV, HCMV, and HIV infections "was held in Paris, Val-de-Grâce, on December 3–4, 2004. The following is a summary of the scientific sessions of this meeting ().
Highlights
The Dominique Dormont Conferences provide an international forum for the promotion of exchanges between clinicians and fundamental scientists, including team leaders and young researchers, involved in interdisciplinary research on chronic infections
They showed that the scaffolding protein HSPG Agrin is expressed at the apical epithelial surface and acts as an attachment factor for HIV-1, by interacting with the gp41 P1 lectin site, synergizing binding to the epithelial receptor galactosyl ceramide
GalCer is expressed in immature dendritic cells and may mediate the internalization of HIV and its transfer to CD4+ cells in a lipid raft-dependent manner, independently of DC-SIGN
Summary
The Dominique Dormont Conferences provide an international forum for the promotion of exchanges between clinicians and fundamental scientists, including team leaders and young researchers, involved in interdisciplinary research on chronic infections. They provide an occasion for researchers with common interests to get together for two or three days of synthesis and intense discussion on the most recent advances in their field, to crystallize new research directions and collaborations. Over the course of two days, stimulating exchanges and discussions between team leaders and young researchers, highlighting key issues in this research field, were achieved, raising hopes of opening the way to further international investigations on interactions between host and viral determinants
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