Abstract
Human coronavirus HKU1 (HCoV-HKU1) is a RNA virus which gets in the human cells by binding to the receptor of N-acetyl-9-O-acetylneuraminic acid. Human Coronaviruses (HCoVs), including HCoV-HKU1, are globally found. HCoV-HKU1 is responsible for upper and lower respiratory tract infections, usually with mild symptoms. In severe cases, HCoV-HKU1 can cause life-threatening respiratory illness especially in vulnerable hosts such as elderly, children and immunocompromised patients. In Greece, Respiratory Syncytial Virus (RSV) and influenza are the most common viruses causing respiratory tract infections. Traditionally, HCoVs are responsible for less than 3% of respiratory infections in Greek population. HCoVs 229E and OC43 have been shown to circulate in Greece. We report the first case of lung infection in an immunocompromised woman due to HCoV-HKU1, that has never been before detected in Greece. HCoV-HKU1 is related to severe disease even in healthy individuals and must be considered in the differential diagnosis of severe respiratory infections.
Highlights
Human coronavirus HKU1 (HCoV-HKU1) is a coronavirus species in humans
Human Coronaviruses (HCoVs)-HKU1 was first described in a 71-year-old man who had returned to Hong Kong from Shenzhen, China in 2004 and developed bilateral pneumonia and acute respiratory distress syndrome [3]
We report the first case of lung infection in an immunocompromised woman due to HCoV-HKU1, that has never been before detected in Greece
Summary
Human coronavirus HKU1 (HCoV-HKU1) is a coronavirus species in humans It is an enveloped, RNA virus which gets in the human cells by binding to the receptor of N-acetyl-9-O-acetylneuraminic acid [1]. Human Coronaviruses (HCoVs), including HCoV-HKU1, are globally found in the humans and are responsible for approximately one-third of human common cold infections In severe cases, they can cause life-threatening pneumonia and bronchiolitis especially in vulnerable hosts such as elderly, children and immunocompromised patients. After the first two days of hospitalization the patient presented with respiratory deterioration and diffuse lung infiltrates (Figure 1B), was intubated and admitted to intensive care unit. Respiratory virus panel test in BA for detection of human respiratory viruses by use of multiplex RT-PCR was performed and revealed HCoV-HKU1. She denied recent travel or contact with a person that had recently returned from a travel abroad
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
