Abstract
Bats have been gaining attention as potential reservoir hosts of numerous viruses pathogenic to animals and man. Issyk-Kul virus, a member of the family Nairoviridae, was first isolated in the 1970s from vespertilionid bats in Central Asia. Issyk-Kul virus has been described as human-pathogenic virus, causing febrile outbreaks in humans with headaches, myalgia and nausea. Here we describe the detection of a novel strain of Issyk-Kul virus from Eptesicus nilssonii in Germany. This finding indicates for the first time the prevalence of these zoonotic viruses in Europe.
Highlights
Bats have been identified as reservoir hosts of several highly pathogenic viruses such as Hendra virus, Nipah virus and SARS v irus[1,2,3,4,5]
Orthonairoviruses are often transmitted by ticks, the vertebrate reservoir host of the viruses remains unknown; the virus has not been found in wild ruminants or other animals in enzootic areas
In a comprehensive study the virome of European bats in nine pools was sequenced and, besides three novel nairoviruses, numerous viruses were identified[12]. In this manuscript we describe the further characterization of a novel Issyk-Kul virus strain PbGER (ISKV PbGER), from German bats by virome sequencing by annotation and phylogeny
Summary
Bats have been identified as reservoir hosts of several highly pathogenic viruses such as Hendra virus, Nipah virus and SARS v irus[1,2,3,4,5]. In this manuscript we describe the further characterization of a novel Issyk-Kul virus strain PbGER (ISKV PbGER), from German bats by virome sequencing by annotation and phylogeny. The total read number after sequencing was 9,806,241 reads of which 7970 were mapping to Issyk-Kul virus (ISKV), a member of the genus Orthonairoviridae.
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