Abstract
BACKGROUND: Balanced chromosomal translocations and inversions are a common source of infertility because chromosomal segregation and/or recombination can result in lethal genetic disease in offspring. To detect unbalanced structural abnormalities and therefore avoid transfer of nonviable embryos, IVF physicians rely on fluorescent in situ hybridization (FISH) for preimplantation genetic diagnosis (PGD). New molecular methods, such as DNA microarrays, might improve these types of analysis. We previously developed and validated methods for DNA microarray-based aneuploidy screening that are compatible with day 5 transfer.
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