Abstract
Chronic granulomatous disease (CGD) is characterized by a defect in phagocytic cells that lead to recurrent bacterial and fungal infections. The etiology of most common fungal infections in CGD are Aspergillus species. Aspergillus nidulans is one of several species of Aspergillus with low pathogenicity. However, it was reported to cause fatal invasive Aspergillosis in patients with CGD. Here we report the first cured invasive Aspergillus nidulans infection with extensive involvement of the spinal cord in a five-year-old child with CGD.
Highlights
Patients with chronic granulomatous disease (CGD) are at risk for fungal infections such as invasive Aspergillosis [1]
The mortality of invasive Aspergillosis is high despite specific antifungal treatment, for cases that involve the spinal cord in Chronic granulomatous disease (CGD) [2]
We add a case of A. nidulans infection that caused extensive spinal cord involvement in a five-year-old boy with CGD
Summary
Patients with chronic granulomatous disease (CGD) are at risk for fungal infections such as invasive Aspergillosis [1]. Introduction Patients with chronic granulomatous disease (CGD) are at risk for fungal infections such as invasive Aspergillosis [1]. The mortality of invasive Aspergillosis is high despite specific antifungal treatment, for cases that involve the spinal cord in CGD [2]. A few cases have been reported for A. nidulans invasive infections, almost exclusively in patients with CGD [3].
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