Abstract
We present epidemiological, clinical and laboratory findings of five Czech patients diagnosed with autochthonous mosquito-borne disease—four patients with confirmed West Nile virus (WNV) and one patient with Usutu virus (USUV) infections, from July to October 2018, including one fatal case due to WNV. This is the first documented human outbreak caused by WNV lineage 2 in the Czech Republic and the first record of a neuroinvasive human disease caused by USUV, which illustrates the simultaneous circulation of WNV and USUV in the country.
Highlights
West Nile virus (WNV) is a mosquito-borne arbovirus belonging to the family Flaviviridae, genus Flavivirus, Japanese encephalitis serocomplex
WNV is a causative agent of West Nile fever, a mosquito-borne disease affecting horses and humans, the latter serving as so-called dead-end hosts [1]
Clinical and laboratory findings collected from five patients diagnosed with WNV or USUV infections
Summary
West Nile virus (WNV) is a mosquito-borne arbovirus belonging to the family Flaviviridae, genus Flavivirus, Japanese encephalitis serocomplex. In nature, it circulates mainly among birds and mosquitoes of genera Culex, Anopheles, Culiseta, Uranotaenia or Coquilletidia. WNV is a causative agent of West Nile fever, a mosquito-borne disease affecting horses and humans, the latter serving as so-called dead-end hosts [1]. Since 2004, highly virulent WNV lineage 2 has appeared in Europe, causing sporadic outbreaks in Hungary (2008), Greece (2010) and Serbia (2012) [2]. Highly virulent WNV lineage 2 (WNV-2) strains have been repeatedly documented in Cx. modestus populations on local fishponds [3,4]. No case of WNV-2 infection in humans had been documented before the 2018 season
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
