Abstract
The derivative spectrophotometric method was established for simultaneous determination of dexamethasone and cytarabine (cytosine arabinoside). Measurements were made in the zero-crossing wavelengths at 268.0 nm (first derivative) and 264.0 nm (third derivative) for determining dexamethasone and cytarabine, respectively. The calibration graphs were linear in the concentration ranges 0.10 to 10 μg/mL of dexamethasone and 0.25 to 50.0 μg/mL of cytarabine. The limits of detection 0.08 and 0.10 μg/mL and relative standard deviations 3.0 and 1.0% were obtained for dexamethasone and cytarabine, respectively. The possible interfering effect of other substances was also studied to investigate selectivity of the developed method. The proposed method was applied satisfactorily for the simultaneous determination of both drugs in the pharmaceutical formulation and biological fluid samples.
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