Abstract
Meeting abstracts Adoptive cell transfer (ACT) of tumor specific T lymphocytes, after host immunodepletion, was shown to mediate objective cancer regression of metastatic melanoma. Effective T cell activation depends, among other factors, on the functional avidity of the peptide-MHC complex (pMHC)
Highlights
Adoptive cell transfer (ACT) of tumor specific T lymphocytes, after host immunodepletion, was shown to mediate objective cancer regression of metastatic melanoma
Unlike antibodies whose affinities improve over time by somatic hypermutation (SHM), T cell receptor (TCR) do not undergo SHM
In our research we developed a system that can increase the affinity of a TCR to its ligand by subjecting TCR genes to somatic hypermutation, directed by the mutator enzyme Activation Induced cytidine Deaminase (AID)
Summary
Adoptive cell transfer (ACT) of tumor specific T lymphocytes, after host immunodepletion, was shown to mediate objective cancer regression of metastatic melanoma. Gozlan et al Journal for ImmunoTherapy of Cancer 2013, 1(Suppl 1):P11 http://www.immunotherapyofcancer.org/content/1/S1/P11 “First AID” for T cell adoptive transfer: TCR affinity maturation by somatic hypermutation Yosi M Gozlan*, Esther Tzehoval, Lea Eisenbach
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