Abstract
ObjectivesOur study aimed to determine the relationship between serum periostin levels, and the neutrophil–lymphocyte ratio (NLR) with ischemic stroke subtypes, clinical stroke scales, and acute prognosis in patients with acute ischemic stroke.Materials and MethodsForty-two ischemic stroke patients and 39 age- and sex-matched healthy volunteers were included in our study. Demographic characteristics including age and gender were recorded. Blood serum periostin and NLR values were evaluated in the first 24 hours after admission. Serum periostin levels were compared with healthy controls of similar age and sex. Lesion localization was determined by cranial CT or diffusion MRI of the patients. Stroke scales were recorded on days 1 and 7 of hospitalization in the study group.ResultsThe mean serum periostin levels were higher than in the control group, but no statistically significant difference was found. There was no correlation between serum periostin levels and prognosis of stroke. First admission NLRs were statistically higher than in the control group. The first admission NLRs were positively correlated with the first admission National Institute of Health Stroke Scale score and the day 7 modified Rankin score.ConclusionOur study is the first study to evaluate both NLR and serum periostin levels in all types of acute ischemic stroke. While our study did not show that first admission serum periostin levels can be used as a biomarker in ischemic stroke, it did indicate that the first admission NLR can be used for acute prognosis of ischemic stroke.
Highlights
Stroke is the third leading cause of death following coronary heart disease and all cancers in both developed countries and worldwide
There was no correlation between serum periostin levels and prognosis of stroke
The first admission neutrophil–lymphocyte ratio (NLR) were positively correlated with the first admission National Institute of Health Stroke Scale score and the day 7 modified Rankin score
Summary
Stroke is the third leading cause of death following coronary heart disease and all cancers in both developed countries and worldwide. The Bamford classification system is an important tool for evaluating ischemic stroke. Patients are divided into four subgroups: partial anterior circulation infarcts, total anterior circulation infarcts, lacunar infarcts, and posterior circulation infarction. Several factors impact life prediction after stroke. The survival rate during the first 30 days is 85%, whereas in hemorrhagic stroke, this rate ranges from 20% to 52%. Mortality is higher in hemorrhagic stroke patients in the first 30 days, whereas mortality increases in ischemic stroke patients over time. There is no definitive information about the prognosis of post-stroke recovery. Many biomarkers have been researched to predict the prognosis of stroke, very few biomarkers are currently being used for follow-up of stroke patients in daily clinical practice
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