Abstract
DRUGMAKER SEPRACOR CANADA pleaded guilty in a Canadian court on May 2 to one charge of failing to provide proper workplace ventilation and will pay a U.S.$47,000 fine for the death of chemist Roland Daigle. Daigle died on Oct. 8, 2008, from lung failure after exposure to trimethylsilyldiazomethane (TMSD) in a quality control laboratory at the company’s Windsor, Nova Scotia, facility. The plea and fine were part of a deal in which the prosecutor dropped four other charges against the company, a subsidiary of Sunovion Pharmaceuticals. The other charges involved hazardous material training, use of personal protective equipment, and maintaining the security of the accident scene. The day before he died, Daigle, 46, worked with TMSD, (CH 3 ) 3 SiCHN 2 , when lab fume hoods were not operating because of roof work. TMSD can be used as a methylating reagent in place of diazomethane, which is explosive. When inhaled, diazomethane can also cause fatal lung damage akin to ...
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