Finnish children carrying the high-risk HLA genotype have a 45-fold increased risk of type 1 diabetes compared to peers with neutral or protective genotypes

Antti-Mathias Taka,Anna But,Johanna Lempainen,Tommi Vatanen,Taina Härkönen,Jorma Ilonen,Mikael Knip

doi:10.1016/j.diabres.2023.110256

Finnish children carrying the high-risk HLA genotype have a 45-fold increased risk of type 1 diabetes compared to peers with neutral or protective genotypes

Antti-Mathias Taka, Anna But + Show 5 more

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https://doi.org/10.1016/j.diabres.2023.110256

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Journal: Diabetes research and clinical practice	Publication Date: Jan 11, 2023
Citations: 1	License type: cc-by

Affiliation: University of Helsinki, Helsinki University Hospital, University of Turku, Turku University Hospital, University of Auckland, Broad Institute, Tampere University

#High-risk Genotype #Protective Genotypes + Show 8 more

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Abstract

The association between HLA genotypes and type 1 diabetes is well known. We set out to examine incidence rates and ratios of type 1 diabetes depending on the risk afflicted by HLA genotype. Children with the high-risk genotype have a 45-fold disease risk compared to peers with neutral or protective genotypes.

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