Abstract
Pharmaceutical high barrier blister packages are manufactured from aluminium-polymer laminate foils (e.g. consisting of PA-Al-PVC layers). By a cold stretch forming process cavities are formed. The aim of this work is to determine a homogenized elastic-plastic description of the laminate by micromechanics. Therefore, a microstructural model is developed where the layers are mapped in a representative volume element. The obtained homogenized material model is applied to simulate the stretch forming to gain more insight into the forming process.
Highlights
Blister packs are often used for the packaging of pharmaceutical tablets
Pharmaceutical high barrier blister packages are manufactured from aluminium-polymer laminate foils
For numerical investigations of the deformation behavior of aluminium-polymer laminate foils a micromechanical finite element (FE) model was developed. This model is based on the representative volume element technique
Summary
Blister packs are often used for the packaging of pharmaceutical tablets. Currently, there are two main types of pharmaceutical blister packages on the market. The other type of package is manufactured by cold stretching of aluminium-polymer laminate foils The aluminium in this composite material serves as barrier layer. The companies developing forming machines for cold forming blister packs often lack knowledge about the exact specification of foils their costumers will use Since they have limited information about the deformation behavior of aluminium-polymer laminate foils, they have to design the punches with high safety factors. Such a method allows to design the punches in an early stage of development and no machine time, for setting up the tools and testing, is wasted One challenge in such a FE-modeling is the description of the mechanical behavior of aluminium-polymer laminate foils, since due to their layered structure their forming behavior and failure behavior is not yet well understood [1]. The three cases with different material descriptions are compared by hypotheses regarding the reasons for failure
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