Abstract
The application of microneedles (MNs) for minimally invasive biological fluid sampling is rapidly emerging, offering a user-friendly approach with decreased insertion pain and less harm to the tissues compared to conventional needles. Here, a finger-powered microneedle array (MNA) integrated with a microfluidic chip was conceptualized to extract body fluid samples. Actuated by finger pressure, the microfluidic device enables an efficient approach for the user to collect their own body fluids in a simple and fast manner without the requirement for a healthcare worker. The processes for extracting human blood and interstitial fluid (ISF) from the body and the flow across the device, estimating the amount of the extracted fluid, were simulated. The design in this work can be utilized for the minimally invasive personalized medical equipment offering a simple usage procedure.
Highlights
microneedle array (MNA) can be inserted into a target area, even within the depth of skin epidermis and they have emerging biomedical applications in drug delivery systems [9,10,11,12] with the capability of programmed deliveries of drug doses for multiple-injection therapies such as vaccination [13], sampling interstitial fluid (ISF) [14,15] biomarker detection [16], enhanced wound healing [17], fertility control [18], point-of-care (POC) setups and diagnostic tests [19,20], DNA extraction [21,22], cancer therapy [23], and force sensing [24]
One of the advantages that MNs and MNA-based devices offer in comparison to the conventional needle technologies is their solution for the fear of needles
MNs can be administrated by patients in the point-of-care settings with minimal pain
Summary
Since their inception in 1976 as a drug delivery device [1] until 2020 where they were regarded as one of the top 10 emerging technologies [2], microneedles (MNs) have presented many advantages in injection processes, including minimizing insertion pain and reducing tissue damage and controlled drug delivery as compared to the conventional needle technologies. MNAs can be inserted into a target area, even within the depth of skin epidermis and they have emerging biomedical applications in drug delivery systems [9,10,11,12] with the capability of programmed deliveries of drug doses for multiple-injection therapies such as vaccination [13], sampling interstitial fluid (ISF) [14,15] biomarker detection [16], enhanced wound healing [17], fertility control [18], point-of-care (POC) setups and diagnostic tests [19,20], DNA extraction [21,22], cancer therapy [23], and force sensing [24]
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