Abstract
The fine-structure of the firing patterns of single units in acute penicillin foci and their homotopic (mirror) regions, was studied in rat neocortex. The results indicate that major differences exist between the activity of primary and dependent secondary focus neurons. Moreover, these differences are apparent even when the paroxysmal field potentials in the primary and secondary foci are grossly similar. There are potential implications of these data for current concepts of epileptogenesis and they have relevance to the problem of independent (chronic) secondary epileptic foci.
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