Abstract
Canonical transient receptor potential (TRPC) channels are elements of the immune cell Ca2+ handling machinery with specific functions limited to particular cell phenotypes. Mast cells play a complex role within the tumour microenvironment. NFAT transcriptional activation in mast cells is considered beneficial for immune defence, while secretion of certain mast cell mediators by degranulation is likely promoting tumour progression. Here we set out to establish a pharmaco-optogenetic protocol for specific control over mast cell function.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
