Abstract
Canonical transient receptor potential (TRPC) channels are elements of the immune cell Ca2+ handling machinery with specific functions limited to particular cell phenotypes. Mast cells play a complex role within the tumour microenvironment. NFAT transcriptional activation in mast cells is considered beneficial for immune defence, while secretion of certain mast cell mediators by degranulation is likely promoting tumour progression. Here we set out to establish a pharmaco-optogenetic protocol for specific control over mast cell function.
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