Abstract
Electron microscopic examination of thiouracil-induced transplanted thyroid tumors reveals numerous histological patterns: 1) Tumor follicles which are characterized by normal-appearing follicular cells but differ from the host’s normal thyroid gland in their having an increased number of light cells. The light cell of the thyroid tumor contains a cytoplasmic matrix that is filled with dense, secretory-like granules. 2) Tumor follicles with grossly reduced luminal spaces. Their follicular cells have much less granular endoplasmic reticulum and a more extensive Golgi apparatus than the host’s normal thyroid cells. 3) Tumor cells which have lost the typical follicular arrangement. These cells are characterized by further alterations in their cytoplasmic elements and, in addition, possess an abundance ofmultivesicular bodies, vacuolated dense myelin-like bodies and whorls of cytoplasmic membranes. It is suggested that the alterations in the granular endoplasmic reticulum may account for the decreased product...
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