Fine Needle Aspiration Cytopathology of Pediatric Lympha denopathy among Sudanese Children

Hussain Gadelkarim Ahmed,Ibraheem Mohmmed Alamin Ashankyty,Rashid Awad Abdallah Salih,Maysa Badawi Elmubasher,Gamal Eldin Mohamed Osman Elhussein

doi:10.7314/apjcp.2013.14.7.4359

Hussain Gadelkarim Ahmed, Ibraheem Mohmmed Alamin Ashankyty + Show 3 more

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https://doi.org/10.7314/apjcp.2013.14.7.4359

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Abstract

Pediatric lymphadenopathy is a challenging medical situation for the child patient, the parents, and the physician. Although the bulk of masses will be benign the fear of malignancy is omnipresent. Therefore, the objective of this study was to identify the common cytopathological patterns of lymphadenopathy among Sudanese children. One hundred pediatric patients presenting with peripheral lymphadenopathy were included in the study, their ages ranging from 2 to 14 years, with a mean age of 7 years. Demographic characteristics, clinical manifestations and FNA materials were prospectively obtained. FNA was performed in 100 cases (100%). There were no technical complications. All cases confirmed adequacy of specimen. Overall, FNA demonstrated 90 (90%) benign lesions and 10 (10%) malignant diagnosis. The benign lesions were reactive lymphoid hyperplasia (n=64), followed by benign granulomatous disease (n=26). Of the 10 cases diagnosed with malignancy, 7 (7%) were cases of non-Hodgkin`s lymphoma and the remaining 3 (3%) were Hodgkin's lymphomas. Pediatric lymphadenopathy is common in Sudan. CLA is the common frequent site. Lymphoma represents a major challenge in this setting.

Highlights

Pediatric lymphadenopathy is a difficult medical condition that is frequently seen in children
One hundred pediatric patients presenting with peripheral lymphadenopathy were included in the study, their ages ranging from 2 to 14 years, with a mean age of 7 years
In this study is a descriptive prospective study conducted on consecutive 100 pediatric patients who referred for Fine Needle Aspiration Cytology (FNAC) of an enlarged peripheral lymph node

Summary

Introduction

Pediatric lymphadenopathy is a difficult medical condition that is frequently seen in children. The majority of these masses will be benign the fear of malignancy is ever present. Cervical lymphadenopathy most commonly represents a transient response to a benign local or generalized infection, but occasionally it might herald the presence of a more serious disorder such as malignancy. Acute unilateral cervical lymphadenitis is caused by streptococcal or staphylococcal infection in 40% to 80% of cases. Generalized lymphadenopathy is often caused by a viral infection, and less frequently by malignancies, collagen vascular diseases, and medications (Alexander, 2004). Pediatric lymphadenopathy is a challenging medical situation for the child patient, the parents, and the physician. FNA demonstrated 90 (90%) benign lesions and 10 (10%) malignant diagnosis.

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