Abstract
Advances in fine-needle aspiration cytology (FNAC) techniques allows for a whole range of procedures on these limited sources of tissue. Where fresh aspirates are not readily available, archival FNAC samples had also been used for clinical diagnoses, molecular profiling, and disease monitoring with impressive results. Nonetheless, legitimate concerns exist regarding the reliability of these banked specimens. Increased demands on human tissues in response to the rapid acceleration on emerging scientific platforms will probably make tissue bank creation derived from archival FNAC a priority. To highlight its future prospects as a resource for tissue banking, this paper provides an overview of the use of archival FNAC in clinical situations and ancillary studies. It is concluded that tissue banks of archival FNAC specimens might have great promise in optimizing patient care and translational research.
Highlights
Tissue banking refers to a chain of activities directed at the collection, storage, and distribution of residual specimens of abnormal and normal human tissues [1]
To explore a possible role for archival fine-needle aspiration cytology (FNAC)-based tissue banks in the emerging scenario, this paper examines the evidence base in major bibliographic databases
Mutational analysis and/or gene copy number is being increasingly used in choosing among a wide range of targeted therapies for nonsmall cell lung cancer (NSCLC) due to the discovery that somatic mutations in the epidermal growth factor receptor (EGFR) gene are associated with sensitivity to the EGFR tyrosine kinase inhibitors (TKIs) in lung adenocarcinomas, whereas KRAS mutations are associated with resistance [28]
Summary
Tissue banking refers to a chain of activities directed at the collection, storage, and distribution of residual specimens of abnormal and normal human tissues [1]. It encompasses a wide range of specimen types and sample collection designs, ranging from population-based banking of normal tissues to specific biobanking of diseased specimens obtained in the course of clinical interventions and autopsies [1,2,3]. Considerable advances in biomedical research had been achieved on high-quality samples derived from large series of cases from well-organized archival FFPE tissue banks. Identified abstracts were independently reviewed, and the findings are presented as a narrative summary
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