Abstract
Multiple Myeloma (MM) is a disseminated plasma cell tumor caused by the proliferation of a single plasma cell clone which results from the production of monoclonal immunoglobulin, most commonly class G (IgG). MM is a cancer of the elderly, with a mean age at diagnosis of 68 years. A 79-year-old white patient sought the outpatient clinic of the Discipline of Stomatology, S?o José dos Campos Dental School, UNESP, because of a fracture associated with an osteolytic lesion in the right ascending ramus of the mandible. In view of the clinical-radiographic findings, exploratory fine needle aspiration (FNA) of the lesion was performed and the sanguinolent material obtained was submitted to the preparations of smears for cytology analysis. The diagnosis of MM was based on laboratory and radiographic findings. FNA cytology analysis of the lesion permitted a diagnostic hypothesis of MM.
Highlights
Multiple Myeloma (MM) is a disseminated plasma cell tumor caused by the proliferation of a single plasma cell clone which results from the production of monoclonal immunoglobulin, most commonly class G (IgG)
The course of MM is associated with different organ dysfunctions such as renal failure, anemia, hypercalcemia, deposition of amyloid substance characterizing excess of immunoglobulin light chains, a reduced immune response, coagulation disorders, recurrent infections, and phenomena related to blood hyperviscosity
Diagnosis is based on laboratory and radiographic findings and depends on three abnormal results: bone marrow containing more than 15% plasma cells; generalized osteopaenia and/or lytic bone lesions on plain film radiography; blood serum and/or urine containing an abnormal protein [5]
Summary
Multiple Myeloma (MM) is a disseminated plasma cell tumor caused by the proliferation of a single plasma cell clone which results from the production of monoclonal immunoglobulin, most commonly class G (IgG). This plasma cell clone proliferates in the bone marrow in an uncontrolled manner, resulting in bone resorption [1,2,3]. Diagnosis is based on laboratory and radiographic findings and depends on three abnormal results: bone marrow containing more than 15% plasma cells (normally no more than 4% of the cells in the bone marrow are plasma cells); generalized osteopaenia and/or lytic bone lesions on plain film radiography; blood serum and/or urine containing an abnormal protein [5]. This article reports a case of Multiple Myeloma showing FNA cytology analysis
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
