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Abstract
The fragile site, FRA16B, at 16q22.100 and four different translocations with breakpoints at 16q22.102, 16q22.105, 16q22.108, and 16q22.3 were used to locate and order DNA probes. This was achieved by Southern analysis of a somatic cell hybrid panel containing portions of chromosome 16 and by in situ hybridization. The anonymous DNA fragments D16S6, D16S10, and D16S11 were proximal to FRA16B and located at 16q13 → q22.100. D16S4 and LCAT were located at 16q22.100 → q22.102. TAT and HP were located at 16q22.105 → q22.108. CTRB was located distal to 16q22.105 and therefore is in the distal half of 16q22. The order of marker in this region was determined as centromere- D16S6, D16S11, D16S10, MT-FRA16B-D16S4, LCAT-HP, TAT, CTRB-APRT-telomere. Linkage studies to determine map distances between the closest markers flanking the fragile site are now in progress.
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