Abstract
One of many important features of the tumour microenvironment is that it is a place of active Darwinian selection where different tumour clones become adapted to the variety of ecological niches that make up the microenvironment. These evolutionary processes turn the microenvironment into a powerful source of tumour heterogeneity and contribute to the development of drug resistance in cancer. Here, we describe a computational tool to study the ecology of the microenvironment and report results about the ecology of the tumour microenvironment and its evolutionary dynamics.
Highlights
The tumour microenvironment is characterized by large chemical gradients and contains a mixture of normal and tumour cells
To identify underlying processes and provide reasoning, we have developed a computational model that is a tool to understand the fine-grained features of a simplified tumour microenvironment, i.e. of a microenvironment that contains only tumour cells and blood vessels
As explained in the introduction, the study of the ecology of the tumour microenvironment at the angiogenic switch is the primary motivation for the work described in this paper and for the development of the presented complex software tool
Summary
The tumour microenvironment is characterized by large chemical gradients and contains a mixture of normal and tumour cells. To identify underlying processes and provide reasoning, we have developed a computational model that is a tool to understand the fine-grained features of a simplified tumour microenvironment, i.e. of a microenvironment that contains only tumour cells and blood vessels.
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