Abstract
Myeloma Initiating Cells (MICs), malignant stem cells originating and disseminating myeloma (MM) are driving relapse and resistance of MM as they possess heterogeneity and plasticity. Features like these are still difficult to overcome by chemo/immuno-therapy only. Therefore restoration of the patient’s immune system ie the patient's tumour surveillance is essential. This can be done by allogeneic transplant of immune system or within the original patient’s one. Viktor Frankl et al discovered that finding the meaning of life has got ability to rebuild the patient’s immune system.
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