Finding and isolation of novel peptides with anti-proliferation ability of hepatocellular carcinoma cells from mung bean protein hydrolysates

Abstract

Abstract Mung bean protein hydrolysate has shown some biological properties. Isolated mung bean proteins were hydrolyzed by papain and tested for antiproliferative effects on cancer cells. It was confirmed that the mung bean peptides could inhibit the proliferation of tumor cells in mice, without the side effects of chemical anticancer drugs, and that the mung bean peptides promoted apoptosis of HepG2 cells and arrested the cell cycle in the S phase at a low dose and the G0/G1 phase at a high dose. Subsequently, the hydrolysates were purified through ultrafiltration and Sephadex G-15 gel chromatography. Fraction A, obtained following size-fractionation (