Abstract
This chapter reviews DNA recognition by T-cell factors (TCFs) and how computational and genome-wide surveys of TCF occupancy are being used to identify Wnt response elements (WREs) and the transcriptional targets that are regulated by the Wnt/β-catenin pathway. One emerging theme from the growing number of genome-wide studies is the existence of cell-specific groups of TFs that colocalize with TCFs. While there are likely multiple mechanisms influencing cell-type-specific TCF-binding patterns, interactions between TCFs and other TFs likely play a major role in this level of regulation. Continued investigation of what (besides TCF-binding sites) defines various WREs, coupled with continued development of bioinformatic tools, will complement the data provided by genome-wide surveys of TCFs and potential cofactors.
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