Abstract
Due to aging of the general population, prevalence of Benign Prostatic Enlargement is increasing. Symptoms of BPE may vary between the patients. Aim of the study was to analyze and compare the usefulness of combination drugs therapy and monotherapy after a trial period of six months. Out of 100 male patients aged 45 years and above diagnosed with BPE, 92 were included in the study. Patients were randomized using computer generated random number table. Of which, 47 patients received combination therapy with Tamsulosin plus Finasteride and 45 patients received monotherapy with Tamsulosin once daily at bed time. The baseline demographic variables were comparable in both groups. The decrease in the total American Urological Association symptom score was statistically significant in the combination group (p<0.0001) as compared to monotherapy (p=0.0715) respectively. There was a statistically significant reduction in the residual urine volume with combination therapy (p<0.0001) than in patients with monotherapy (p= 0.1271). The combination therapy is effective in decreasing the irritative and obstructive symptoms in patients with BPE than monotherapy.
Highlights
Due to aging of the general population, prevalence of Benign Prostatic Enlargement is increasing
Patients were randomized into two groups using computer generated random number tables such that 50 patients received combination drug therapy of Tamsulosin 0.4 mg plus Finasteride 5mg and remaining 50 patients received monotherapy with Tamsulosin 0.4 mg every day at bed time for a duration of six months
Patients aged 45 years and above with symptomatic Benign enlargement of prostate (BPE) as categorized by American Urological Association (AUA) symptom scoring system were included in the study.[4]
Summary
Due to aging of the general population, prevalence of Benign Prostatic Enlargement is increasing. Symptoms of BPE may vary between the patients. Aim of the study was to analyze and compare the usefulness of combination drugs therapy and monotherapy after a trial period of six months. Benign enlargement of prostate (BPE) is a common problem in aging males. At the age of 40, 5 to 10% of men have prostate enlargement whereas at 80 years, prevalence is as high as 80%.1. Correspondence: Dr Binod Bade Shrestha, Department of Shrestha et al Finasteride and Tamsulosin Combination in Benign Prostatic Enlargement in a Tertiary Hospital. The impact of Lower Urinary Tract Symptoms (LUTS) on patient's quality of life is variable. The patient's perception of severity of condition and the degree to which it interferes with his lifestyle should be the primary consideration in choosing therapy
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