Abstract
The goal of this study was to compare the adult height outcomes of 201 hypopituitary children treated at CHOB with standardized doses of either pGH (n=106, 0.3u/kg/week = 0.15 mg/kg/wk rGH approximately, three times weekly (TIW), IM or SC) or rGH (n=95, 0.3 mg/kg/wk TIW or daily SC). During the pGH era (1964-1985) GH treatment was given 9 -12 months each year in contrast to the rGH era when treatment was continuous. All patients exhibited a peak GH response to two provocative tests of <10 ng/ml(polyclonal radioimmunoassay).
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