Abstract
We demonstrate a novel microfluidic device to detect living parasites from native blood using monolithic polydimethylsiloxane (PDMS) structures. Several blood-borne and tick-borne parasites such as dirofilariosis can be investigated by this microcapillary system. Inside this microfluidic device, a special flow-through separator structure has been implemented which contains a cylindrical active zone, where the microfilariae or other few micron-size pathogens remain trapped. The center region is partially surrounded by microcapillaries which are positioned along an isobaric line to aid in filtration efficiency through pressure equalization. The developed test can be optimized for a specific nematode or pathogen detection by adjusting the capillary width.
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