Abstract
This work presents a study of film coating with the vaginal strain of Lactobacillus acidophilus, the aim of which was to manufacture administrable probiotic tablets in one step and to enhance the survival rate of bacteria and their viability during storage. The results show that the film coated lactose-based tablets contained viable bacteria and the survival rate after the process was 21%, which could be enhanced up to 59% by applying protective media (trehalose, sucrose, reconstituted skim milk (RSM) during dehydration. Additionally, protective agents improved the viability of bacteria during storage too. After one year, 20% of the embedded bacteria were active when stored at –20°C, and viability dropped only one order of magnitude when stored at 7°C. It was verified that the bacteria in film coated tablets were not sensitive to higher levels of humidity owing to the moisture-moderating PVA-based coating composite.
Highlights
The consumption of probiotic products is expected to increase in following years owing to the wide range of positive effects associated with their application [1]
This work presents a study of film coating with the vaginal strain of Lactobacillus acidophilus, the aim of which was to dry the bacteria and manufacture probiotic tablets in one step and to enhance the survival rate of bacteria and their viability during storage
The results show that the film coated lactose-based tablets contained viable bacteria and the survival rate after the process was 21 %, which could be enhanced up to 59 % by applying protective media (trehalose, sucrose, reconstituted skim milk (RSM)) during dehydration
Summary
The consumption of probiotic products is expected to increase in following years owing to the wide range of positive effects associated with their application [1]. Our aim was to develop an industrially feasible alternative way of solid formulation of bioproducts through the example of Lactobacillus acidophilus (LBA). This type of bacteria is one of the most widely investigated and applied species, especially in the field of dairy industry, and it is an important part of normal human bacterial flora located usually in mouth, in the gastrointestinal tract and in the urinary and genital tracts of females [3, 4]. Bacterial vaginosis (BV) is a common infection caused by an imbalance of normal vaginal micro flora This is in connection with the deficiency of Lactobacillus bacteria, which are replaced by undesirable exogenous microorganisms [5]. Intra-vaginal administration of Lactobacillus acidophilus has a better capability to cure BV compared to reference treatments, such as metronidazole
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